| Sunday, April 18, 2021 | ||
| Osasuna | 13:00 | Elche |
| Real Sociedad | 13:00 | Sevilla |
| Deportivo Alavés | 15:15 | Huesca |
| Atlético de Madrid | 15:15 | Eibar |
| Real Betis | 17:30 | Valencia |
| Cádiz | 17:30 | Celta Vigo |
| Getafe | 20:00 | Real Madrid |
| Levante | 20:00 | Villarreal |
| Wednesday, April 21, 2021 | ||
| Levante | 18:00 | Sevilla |
| Osasuna | 18:00 | Valencia |
| Real Betis | 19:00 | Athletic Bilbao |
| Deportivo Alavés | 20:00 | Villarreal |
| Elche | 20:00 | Real Valladolid |
| Cádiz | 21:00 | Real Madrid |
| Thursday, April 22, 2021 | ||
| Atlético de Madrid | 18:00 | Huesca |
| Granada | 20:00 | Eibar |
| Real Sociedad | 20:00 | Celta Vigo |
| Barcelona | 21:00 | Getafe |
| Sunday, January 17, 2021 | ||
Aston Villa  | 02:00 |  Everton |
| Friday, April 16, 2021 | ||
| Everton | 20:00 |  Tottenham Hotspur |
| Saturday, April 17, 2021 | ||
Southampton  | 01:00 |  Crystal Palace |
Newcastle United  | 12:30 |  West Ham United |
| Wolverhampton Wanderers | 20:15 | Sheffield United |
| Sunday, April 18, 2021 | ||
Arsenal  | 13:30 | Fulham |
Manchester United  | 16:00 | Burnley |
| Monday, April 19, 2021 | ||
| Leeds United | 20:00 |  Liverpool |
| Tuesday, April 20, 2021 | ||
Chelsea  | 20:00 | Brighton & Hov… |
| Wednesday, April 21, 2021 | ||
| Tottenham Hotspur | 18:00 | Southampton |
| Aston Villa | 20:15 |  Manchester City |
| Thursday, April 22, 2021 | ||
Leicester City  | 20:00 |  West Bromwich Albion |
| Friday, April 23, 2021 | ||
| Arsenal | 20:00 | Everton |
| Saturday, April 24, 2021 | ||
| Liverpool | 12:30 | Newcastle United |
| West Ham United | 17:30 | Chelsea |
| Sheffield United | 20:00 | Brighton & Hov… |
| Sunday, April 25, 2021 | ||
| Wolverhampton Wanderers | 12:00 | Burnley |
| Leeds United | 14:00 | Manchester United |
| Aston Villa | 19:00 | West Bromwich Albion |
| Monday, April 26, 2021 | ||
| Leicester City | 20:00 | Crystal Palace |