| Monday, December 6, 2021 | ||
| Getafe | 21:00 | Athletic Bilbao |
| Friday, December 10, 2021 | ||
| Mallorca | 21:00 | Celta Vigo |
| Saturday, December 11, 2021 | ||
| Espanyol | 14:00 | Levante |
| Alaves | 16:15 | Getafe |
| Valencia | 18:30 | Elche |
| Athletic Bilbao | 21:00 | Sevilla |
| Sunday, December 12, 2021 | ||
| Villarreal | 14:00 | Rayo Vallecano |
| Osasuna | 16:15 | Barcelona |
| Real Betis | 18:30 | Real Sociedad |
| Real Madrid | 21:00 | Atlético de Madrid |
| Monday, December 13, 2021 | ||
| Cadiz | 21:00 | Granada |
| Friday, December 17, 2021 | ||
| Celta Vigo | 21:00 | Espanyol |
| Saturday, December 18, 2021 | ||
| Rayo Vallecano | 14:00 | Alaves |
| Real Sociedad | 16:15 | Villarreal |
| Barcelona | 18:30 | Elche |
| Sevilla | 21:00 | Atlético de Madrid |
| Sunday, December 19, 2021 | ||
| Granada | 14:00 | Mallorca |
| Athletic Bilbao | 16:15 | Real Betis |
| Getafe | 18:30 | Osasuna |
| Real Madrid | 21:00 | Cadiz |
| Sunday, November 28, 2021 | ||
| Burnley | 01:00 |  Tottenham Hotspur |
| Monday, December 6, 2021 | ||
Everton  |
21:00 |  Arsenal |
| Friday, December 10, 2021 | ||
| Brentford | 21:00 |  Watford |
| Saturday, December 11, 2021 | ||
Manchester City  |
13:30 | Wolverhampton Wanderers |
| Arsenal |
16:00 |  Southampton |
Chelsea  |
16:00 | Leeds United |
Liverpool  |
16:00 |  Aston Villa |
Norwich City  |
18:30 |  Manchester United |
| Sunday, December 12, 2021 | ||
| Brighton & Hov… | 15:00 | Tottenham Hotspur |
| Burnley | 15:00 |  West Ham United |
Leicester City  |
15:00 |  Newcastle United |
Crystal Palace  |
17:30 | Everton |
| Tuesday, December 14, 2021 | ||
| Brentford | 20:30 | Manchester United |
| Norwich City |
20:45 | Aston Villa |
| Manchester City |
21:00 | Leeds United |
| Wednesday, December 15, 2021 | ||
| Brighton & Hov… | 20:30 | Wolverhampton Wanderers |
| Burnley | 20:30 | Watford |
| Crystal Palace |
20:30 | Southampton |
| Arsenal |
21:00 | West Ham United |