| Saturday, January 9, 2021 | ||
| Atlético de Madrid | 16:15 | Athletic Bilbao |
| Monday, January 25, 2021 | ||
| Athletic Bilbao | 21:00 | Getafe |
| Friday, January 29, 2021 | ||
| Real Valladolid | 21:00 | Huesca |
| Saturday, January 30, 2021 | ||
| Eibar | 14:00 | Sevilla |
| Real Madrid | 16:15 | Levante |
| Valencia | 18:30 | Elche |
| Villarreal | 21:00 | Real Sociedad |
| Sunday, January 31, 2021 | ||
| Getafe | 14:00 | Deportivo Alavés |
| Cádiz | 16:15 | Atlético de Madrid |
| Granada | 18:30 | Celta Vigo |
| Barcelona | 21:00 | Athletic Bilbao |
| Monday, February 1, 2021 | ||
| Real Betis | 21:00 | Osasuna |
| Friday, February 5, 2021 | ||
| Deportivo Alavés | 21:00 | Real Valladolid |
| Saturday, February 6, 2021 | ||
| Levante | 14:00 | Granada |
| Huesca | 16:15 | Real Madrid |
| Elche | 18:30 | Villarreal |
| Sevilla | 21:00 | Getafe |
| Monday, December 28, 2020 | ||
Everton  | 01:00 |  Manchester City |
| Sunday, January 3, 2021 | ||
| Burnley | 01:00 | Fulham |
| Wednesday, January 13, 2021 | ||
Aston Villa  | 01:00 |  Tottenham Hotspur |
| Sunday, January 17, 2021 | ||
| Aston Villa | 01:00 | Everton |
| Wednesday, January 20, 2021 | ||
| Leeds United | 01:00 |  Southampton |
| Tuesday, January 26, 2021 | ||
Crystal Palace  | 19:00 |  West Ham United |
Newcastle United  | 19:00 | Leeds United |
West Bromwich Albion  | 21:15 | Manchester City |
| Southampton | 21:15 |  Arsenal |
| Wednesday, January 27, 2021 | ||
| Burnley | 19:00 | Aston Villa |
Chelsea  | 19:00 | Wolverhampton Wanderers |
| Brighton & Hov… | 20:30 | Fulham |
| Everton | 21:15 |  Leicester City |
Manchester United  | 21:15 | Sheffield United |
| Thursday, January 28, 2021 | ||
| Tottenham Hotspur | 21:00 |  Liverpool |