| Friday, August 13, 2021 | ||
| Brentford | 20:00 |  Arsenal |
| Saturday, August 14, 2021 | ||
Manchester United  | 12:30 | Leeds United |
| Burnley | 15:00 | Brighton & Hov… |
Chelsea  | 15:00 |  Crystal Palace |
Everton  | 15:00 |  Southampton |
Leicester City  | 15:00 | Wolverhampton Wanderers |
Watford  | 15:00 |  Aston Villa |
Norwich City  | 17:30 |  Liverpool |
| Sunday, August 15, 2021 | ||
Newcastle United  | 14:00 |  West Ham United |
Tottenham Hotspur  | 16:30 |  Manchester City |
| Saturday, August 21, 2021 | ||
| Liverpool | 12:30 | Burnley |
| Manchester City | 15:00 | Norwich City |
| Aston Villa | 15:00 | Newcastle United |
| Leeds United | 15:00 | Everton |
| Crystal Palace | 15:00 | Brentford |
| Brighton & Hov… | 17:30 | Watford |
| Sunday, August 22, 2021 | ||
| Southampton | 14:00 | Manchester United |
| Wolverhampton Wanderers | 14:00 | Tottenham Hotspur |
| Arsenal | 16:30 | Chelsea |
| Monday, August 23, 2021 | ||
| West Ham United | 20:00 | Leicester City |