| Saturday, September 21, 2019 | ||
| Granada | 20:00 | Barcelona |
| Sunday, September 22, 2019 | ||
| Getafe | 11:00 | Mallorca |
| Espanyol | 13:00 | Real Sociedad |
| Valencia | 15:00 | Leganes |
| Athletic Bilbao | 17:30 | Deportivo Alavés |
| Sevilla | 20:00 | Real Madrid |
| Tuesday, September 24, 2019 | ||
| Real Valladolid | 18:00 | Granada |
| Real Betis | 19:00 | Levante |
| Barcelona | 20:00 | Villarreal |
| Wednesday, September 25, 2019 | ||
| Mallorca | 18:00 | Atlético de Madrid |
| Leganes | 18:00 | Athletic Bilbao |
| Valencia | 19:00 | Getafe |
| Real Madrid | 20:00 | Osasuna |
| Thursday, September 26, 2019 | ||
| Eibar | 18:00 | Sevilla |
| Celta de Vigo | 19:00 | Espanyol |
| Real Sociedad | 20:00 | Deportivo Alavés |
| Friday, September 27, 2019 | ||
| Villarreal | 20:00 | Real Betis |
| Sunday, September 22, 2019 | ||
West Ham United  | 14:00 |  Manchester United |
Crystal Palace  | 14:00 | Wolverhampton Wanderers |
Chelsea  | 16:30 |  Liverpool |
Arsenal  | 16:30 |  Aston Villa |
| Saturday, September 28, 2019 | ||
| Sheffield United | 12:30 | Liverpool |
Tottenham Hotspur  | 15:00 |  Southampton |
| Crystal Palace | 15:00 |  Norwich City |
| Wolverhampton Wanderers | 15:00 |  Watford |
| Chelsea | 15:00 | Brighton & Hov… |
AFC Bournemouth  | 15:00 | West Ham United |
| Aston Villa | 15:00 | Burnley |
Everton  | 17:30 |  Manchester City |
| Sunday, September 29, 2019 | ||
Leicester City  | 16:30 |  Newcastle United |
| Monday, September 30, 2019 | ||
| Manchester United | 20:00 | Arsenal |
| Saturday, October 5, 2019 | ||
| Brighton & Hov… | 12:30 | Tottenham Hotspur |
| Norwich City | 15:00 | Aston Villa |
| Watford | 15:00 | Sheffield United |
| Liverpool | 15:00 | Leicester City |
| Burnley | 15:00 | Everton |
| West Ham United | 17:30 | Crystal Palace |